Maclura pomifera (Moraceae family) has a great many common names besides Osage Orange: bois d’arc, bodark, horse apple, hedge apple, murier du Texas
It’s in the same family as mulberry and has a similar growth habitat and widespread adaptability.
For our ancestors it was a highly prized tree that went out of favor in late Colonial times after the widespread use of barbed wire and later heavy harvesting machinery. Before that time it had multiple crucial uses as a wind break, in preventing soil erosion and especially for creating living hedges for livestock containment. It was also used for it’s very hard but flexible wood in making bows and rot-resistant building materials.
It was also used as a rodent and insect repellant and many still use it for this purpose.
But here we are most interested in its many medicinal uses.
There are plenty of anecdotal stories of cancer cures, like this one:
Randy-Wilson
Biological Application of the Allopathic Characteristics of the Genus Maclura: A Review
“The fruit of M. pomífera has shown an effect on human cancer cells (kidney, lung, prostate, breast, melanoma, and colon) as an inhibitor of histone deacetylase (HDAC) via the prenylated flavonoid pomiferin, showing antiproliferative activity in the six cell lines evaluated [23]. In this sense, the compound pomiferin (contained in the fruit of M. pomífera) has been shown in tests with cancer cells to behave as an inhibitor of cancer stem cells from a human glioma [22], showing a reduction in the expression of genes associated with stamina (the ability of the cell to reproduce repeatedly and form stem cells). Also, M. pomífera has been helpful as a marker in the diagnosis of cancer since it allows the distinguishing of patients with prostate cancer from those patients who present benign prostatic diseases and normal subjects, this being through the high affinity of the sera of patients with prostate cancer towards the M. pomífera lectin [21].
Additionally, the fruit, bark, leaves, root, and seed have been reported to have a high content of oils, sugars, and compounds such as isoflavones, xanthones, triterpenes, and stilbenes, with isoflavones being the most representative [15].”
“The seeds are edible and the heartwood, bark and roots contain many extractives of actual and potential value in food processing, pesticide manufacturing, and dye-making. Various parts of the Maclura species are used in folkloric medicine worldwide. Decoction prepared from the roots of M. pomifera is used for the treatment of sore eyes by Comanche Indians in the North America (Carlson and Volney, 1940). The bark of Maclura tinctoria has been reported to be used against toothache by Kaiowa and Guarani indigenous people living in the Caarapo Reserve in Brazil as well as the in the other parts of Amazon region, it was also recorded to be used in Southern Ghana for dental health (Elvin-Lewis et al., 1980, Elvin-Lewis and Lewis, 1983, Bueno et al., 2005).
The fruit of M. pomifera is also well-known for its rich isoflavonoid content as well as a content of xanthones (Delle Monache et al., 1984, Delle Monache et al., 1994, Toker and Erdogan, 1998). Several biological activities of the plant were reported up to date including antimicrobial, estrogenic, anti-inflammatory and antinociceptive activities (Mahmoud, 1981, Maier et al., 1995, Küpeli et al., 2006). Antioxidant activity of the major flavonoids of M. pomifera has also been studied (Tsao et al., 2003, Vesela et al., 2004).”
Native Americans used M. pomifera for the
treatment of cancer [2]. In Bolivia, the plant sap is used for the treatment of tooth pain, and the bark and leaves are used for uterine hemorrhage [3]. Comanche Indians in North America used the Osage orange roots decoction to treat sore eyes [4]. M. pomifera and its components possess
several biological activities including cytotoxic, antitumor, antibacterial, estrogenic, antifungal, antiviral, and antimalar-ial activities [5–13]. Recently, isofavones isolated from Osage orange have been demonstrated to protect brain cells, or neurons, from the toxic effects of amyloid beta peptide, which is believed to be responsible for the degeneration of neurons in Alzheimer’s disease patients.”
M.pomifera produces several secondary metabolites belonging to diferent chemical classes including prenylated favonoids. Teprenylated favonoids possess diferent biological activities such as antifungal, antibacterial, antitumor, and antioxidant activities.”
We have a few still around in our area and I’ve been propagating them from seed in the hope of creating a living hedge. Unfortunately our summers have been so severe lately I’ve only managed one survivor, now 3 years old. I’ll keep trying!
A very old specimen at a neighbor’s house in East Texas.
Spring 2023
A beautiful shade tree with so much to offer, I hope it becomes popular once again in our countryside.
A couple more impressive Bois d’arc photos from the Internet:
